Genetica
Monoclonal Origin of Multicentric Kaposi's Sarcoma Lesions
NEJMMonoclonal
Origin
of
Multicentric
Kaposi's
Sarcoma
LesionsCharles
S.
Rabkin,
M.D.,
Siegfried
Janz,
M.D.,
Alex
Lash,
M.D.,
Allen
E.
Coleman,
Elizabeth
Musaba,
M.D.,
Lance
Liotta,
M.D.,
Ph.D.,
Robert
J.
Biggar,
M.D.,
and
Zhengping
Zhuang,
M.D.,
Ph.D.
ABSTRACT
Background
Kaposi's
sarcoma
has
features
of
both
hyperplastic
proliferation
and
neoplastic
growth.
Multiple
lesions,
in
which
spindle
cells
are
prominent,
often
arise
synchronously
over
widely
dispersed
areas.
We
tested
the
hypothesis
that
the
spindle
cells
in
these
multicentric
lesions
originate
from
a
single
clone
...continua
Archivio
Hungarian physician and dermatologist, born October 23, 1837, Kaposvár; died March 6, 1902.
