Patogenesi
"Genetica"
Monoclonal Origin of Multicentric Kaposi's Sarcoma Lesions
NEJMMonoclonal
Origin
of
Multicentric
Kaposi's
Sarcoma
LesionsCharles
S.
Rabkin,
M.D.,
Siegfried
Janz,
M.D.,
Alex
Lash,
M.D.,
Allen
E.
Coleman,
Elizabeth
Musaba,
M.D.,
Lance
Liotta,
M.D.,
Ph.D.,
Robert
J.
Biggar,
M.D.,
and
Zhengping
Zhuang,
M.D.,
Ph.D.
ABSTRACT
Background
Kaposi's
sarcoma
has
features
of
both
hyperplastic
proliferation
and
neoplastic
growth.
Multiple
lesions,
in
which
spindle
cells
are
prominent,
often
arise
synchronously
over
widely
dispersed
areas.
We
tested
the
hypothesis
that
the
spindle
cells
in
these
multicentric
lesions
originate
from
a
single
clone
...continua
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"Fattori di rischio"
AIDS: Goedert's Corrispondence
Correspondence
AIDS
2009,
23:273–278
Nonsmoking
and
other
cofactors
for
Kaposi’s
sarcoma
The
recent
series
of
28
cases
of
HIV-negative
Kaposi’s
sarcoma
in
homo/bisexual
men
reported
by
Lanternier
et
al.
[1],
as
well
as
the
subsequent
editorial
comment
by
Colman
and
Blackbourn
[2],
highlights
the
strong
contribution
of
cofactors
to
the
development
of
this
malignancy.
The
primary
cause
of
Kaposi’s
sarcoma
is
infection
with
Kaposi’s
sarcoma
associated
herpesvirus
(KSHV,
also
known
as
human
herpesvirus
8),
but
the
vast
majority
of
KSHV-infected
people
...continua
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